To assess the pharmacokinetics of AZD1656, and its metabolite, in type 2 diabetes mellitus patients with varying degrees of renal impairment and to compare the results with those in patients with normal renal function.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
21
Single dose oral tablet
Research Site
Orlando, Florida, United States
Research Site
Overland Park, Kansas, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Knoxville, Tennessee, United States
Change-from-baseline variables will be calculated for the safety variables listed below, as the post-treatment value minus the value at baseline
Time frame: The baseline values will be as follows:
To evaluate the safety of AZD1656 in T2DM patients with various degrees of renal impairment. To describe the pharmacodynamics of AZD1656 in T2DM patients with various degrees of renal impairment by assessment of 24-hours glucose profile
Time frame: blood samples will be collected for up to 48 hours postdose and urine samples for up to 12 hours postdose for measurement of plasma and urine concentrations of AZD1656 and its metabolite
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