Escalating Ketamine Doses and Pre-emption

Tel-Aviv Sourasky Medical Center120 enrolled

Overview

Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures. We assessed the effects of multiple and escalating doses of ketamine administered many hours before surgery on postoperative pain and analgesia consumption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Postoperative Pain Management

Interventions

KetamineDRUG

group receiving one injection (25 mg) of ketamine (K1) intramuscularly (IM) at 3-4 hours before surgery or placebo (saline 0.9%, NS)

ketamineDRUG

ketamine at 11-12 hours (10 mg) and 3-4 hours (25 mg) before surgery (K2), with a corresponding NS group

ketamineDRUG

ketamine injected IM 17-18, 11-12, and 3-4 hours before surgery (5, 10 and 25 mg, respectively) (K3), and the second group received NS

Eligibility

Sex: ALLMin age: 15 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Consecutive patients, who were scheduled to undergo general or orthopedic oncologic surgery under general anesthesia Exclusion Criteria: 1. allergy to opioids, ketamine or non-steroidal anti-inflammatory drugs (NSAIDs) 2. history of lasting chronic pain or psychiatric disorders or had used opioids or psychotropic drugs of any sort during the past two weeks 3. soldiers and pregnant women

Locations (1)

Tel Aviv Medical Center

Tel Aviv, Israel

Outcomes

Primary Outcomes

postoperative pain

Time frame: 48 hours

Secondary Outcomes

opioid drug consumption

Time frame: 48 hours

Data from ClinicalTrials.gov

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