Study hypotheses is that Antiparasitic therapy in patients with chronic diarrhea after travel to a developing country, with a negative stool findings, will be significantly effective in eliminating diarrhea and other gastro-intestinal complaints compared to similar patients receiving placebo.
It is common to encounter travelers from developing countries who suffer from persistent diarrhea after returning home. In many cases repeated stool samples are negative for bacteria, parasites and helminthes and the cause of the diarrhea is not found. The main debate is whether this condition is a persistent parasitic infection (unidentified) or post-infectious irritable bowel syndrome.However, clinical experience suggests that some of these travelers respond to antiparasitic therapy. This study aims to answer the question whether antiparasitic treatment in these cases is beneficial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Tinidazole 2 gr/daily for 2 days followed by Albendazole 400mg X2 /day for 7 days
2 placebo pills X2 /day for 2 days followed by 1 placebo Pill X2 / day for 7 days
Chaim Sheba Medical Center, Tel Hashomer, Israel
Ramat Gan, Israel
NOT_YET_RECRUITINGSheba Medical Center
Ramat Gan, Israel
RECRUITINGimprovement in gastrointestinal complaints
Time frame: 3 months
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