Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement

Seoul National University Hospital66 enrolled

Overview

The purpose of this study is to evaluate the safety and effectiveness of the peripheral IV continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central IV continuous infusion method.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Coronary Artery Disease Myocardial Ischemia

Interventions

FFR via central venous lineOTHER

Patients with intermediate coronary artery stenosis were consecutively enrolled. FFR was measured by a standard intravenous (IV) adenosine infusion (140 μg•min-1•kg-1) via Rt central femoral vein.

FFR via peripheral venous lineOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * non -infarct related, patients with moderate coronary artery stenosis * normal ejection fraction on echocardiogram Exclusion Criteria: * infarct-related arteries or clinically unstable state * collateral blood flow to the target vessel is shown * atrioventricular block on electrocardiogram * reduced ejection fraction(\<50%) or left ventricular hypertrophy on echocardiography * contraindication of adenosine

Locations (1)

Cardiovascular Center, Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

compare fractional flow reserve at maximal hyperemia

Time frame: interval of 10 minutes

Secondary Outcomes

compare the time to maximal hyperemia and changes in heart rate

Time frame: interval of 10 minutes

Data from ClinicalTrials.gov

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