Efficacy and Safety of Titrated Oral Misoprostol Solution for Labor Induction at Term

University of Manitoba250 enrolled

Overview

The purpose of this study is to determine whether a titrated solution of oral Misoprostol is safe and effective at inducing labor at term, regardless of Bishop Score.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

250

Conditions

Labor Induction at Term

Interventions

MisoprostolDRUG

titrated oral misoprostol solution

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 44 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. term, 2. singleton 3. no contraindication to prostaglandins 4. vertex 5. no exposure to vaginal prostaglandins in the index pregnancy Exclusion Criteria: 1. parity \> 3 2. severe PIH: BP\> 160/100, abnormal LFT's, proteinuria \>1g/day 3. previous uterine surgery 4. regular uterine contractions 5. maternal age \> 45 6. twins

Locations (1)

St. Boniface General Hospital

Winnipeg, Manitoba, Canada

Outcomes

Primary Outcomes

Rate of vaginal delivery within 24 hours

Time frame: 24 hours

Secondary Outcomes

Uterine hyperstimulation rate

Time frame: 24 hours

Data from ClinicalTrials.gov

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