Trichuris Suis Ova in Peanut and Tree Nut Allergy

Inclusion Criteria: * 18 to 64 years old * Positive skin-prick test to peanut or tree nut and a history of significant clinical symptoms within 60 minutes after the ingestion of peanuts or tree nuts. * Peanut or tree nut allergy of mild to moderate grade based on the presence of localized or generalized erythema/urticaria/angioedema/oral pruritis, gastrointestinal symptoms, rhinoconjunctivitis, or mild laryngeal edema (voice change/tightening of throat/mild asthma), and the absence of symptoms/signs of severity (marked dyspnea, hypoxia, cyanosis, hypotension, confusion, incontinence, collapse or loss of consciousness) * Otherwise in good health * Ability to provide written informed consent Exclusion Criteria: * History of severe anaphylaxis to peanut as defined by hypoxia, hypotension, or neurological compromise (cyanosis or SpO2 \< 92% at any stage, confusion, collapse, loss of consciousness, or incontinence) * Poor control of atopic dermatitis or current flare requiring an increase in atopic dermatitis medication * Inability to discontinue antihistaminic for skin testing * Severe persistent asthma as defined by the NHLBI criteria * Asthma that requires oral steroids * Asthma that has been controlled for less than 1 year * FEV1\<80% at the screening visit or immediately before the 1st administration of TSO * Currently being treated with greater than medium daily doses of inhaled corticosteroids, as defined by the NHLBI guidelines * Abnormal blood cell count * Abnormal renal function (creatinine above twice the upper limit of normal range) * Abnormal hepatic tests (AST, ALT above twice the upper limit of normal range) * Allergy to Trichuris species * Currently treated with anti-helminthic medication * Previous treatment with immunosuppressive therapy, cytotoxic chemotherapy or lymphoid irradiation for any reason * Insulin dependent diabetes * History of HIV-1, HTLV-1 or Lyme disease * Significant physical or mental disease that would preclude successful compliance and participation in the study, or, in the opinion of the investigators, constitute a hazard, such that enrollment in the study would not be in the subject's best interest * Presence or history of cancer of any type except successfully treated basal cell or squamous cell carcinoma of the skin * History of alcohol or drug abuse in the last 12 months; chronic liver or biliary disease * Pregnancy and lactation; women of child bearing potential must have a documented negative pregnancy test at entry and at each visit during the study, and must be willing to practice adequate birth control during the duration of the study * History of parasitism or positive stool determination for ova or parasite at screening * Unwillingness or inability of patients (or caregivers) to give written consent or to follow the protocol successfully, including coming to the clinic every 2 weeks for about 4 months * Currently participating in a study using an investigational new drug * Participation in any interventional study for the treatment of food allergy in the past 6 months * Presence in the household of an immunodeficient or immunosuppressed individual