The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
12
3 mg/kg IV priming dose + 2 mg/kg/hr IV infusion for 1 hour
6 mg/kg IV priming dose + 4 mg/kg/hr IV infusion for 1 hour
4.5 mg/kg IV priming dose + 3 mg/kg/hr IV infusion for 1 hour
Departments of Medical Research
Holstebro, Holstebro, Denmark
Systolic blood pressure
Time frame: 6 hours
GFR
Time frame: 6 hours
Arterial Stiffness
Time frame: 6 hours
Fractional excretion of sodium
Time frame: 6 hours
Fractional excretion of potassium
Time frame: 6 hours
Plasma renin concentration
Time frame: 6 hour
Plasma angiotensin II
Time frame: 6 hours
Plasma aldosterone
Time frame: 6 hour
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Isotonic saline solution IV priming dose + IV infusion for 1 hour