To determine whether the combination of nifedipine GITS and valsartan is more effective in reducing central blood pressure than nifedipine GITS or valsartan alone, and to determine whether nifedipine GITS is comparable to valsartan
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
365
Combination treatment with nifedipine GITS 30mg and valsartan 80mg, Once daily
Nifedipine 60mg, Once daily
Valsartan 160mg, Once daily
Unnamed facility
Goyang, Gyeonggido, South Korea
Unnamed facility
Goyang-si, Gyeonggido, South Korea
Unnamed facility
Chungchungbuk-do, Korea, South Korea
Central systolic blood pressure
Time frame: Week 8
Change in central diastolic blood pressure and pulse pressure
Time frame: Week 4,8
Change in central systolic blood pressure
Time frame: Week 4
Change in brachial systolic blood pressure and diastolic blood pressure
Time frame: Week 4,8
Change in brachial pulse pressure
Time frame: Week4,8
Change in augmentation index and augmentation pressure
Time frame: Week 4,8
Response rate(≥10 mmHg decrease of brachial SBP and ≥5mmHg decrease of brachial DBP)
Time frame: Week 4,8
Control rate (≤140/90 mmHg, 130/80 mmHg for diabetes, of brachial BP
Time frame: Week 4,8
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Unnamed facility
Seoul, Korea, South Korea
Unnamed facility
Seoul, Seoul Teugbyeolsi, South Korea
Unnamed facility
Busan, South Korea
Unnamed facility
Gwangju, South Korea
Unnamed facility
Joong-gu, South Korea
Unnamed facility
Kungki-do, South Korea
Unnamed facility
Seoul, South Korea
...and 5 more locations