Safety and the Efficacy of a Sublingual Administration of Flumazenil to Reverse the Effect of Hypnotic Drugs in Healthy Adults

Inclusion Criteria: 1. The subject understood and voluntarily signed an informed consent form prior to any study-mandated procedure. 2. Male or female aged 18-65 at screening. Women of childbearing potential must have a negative pregnancy test at the screening visit and use a reliable method of contraception during the entire study duration (e.g. Contraceptive pill; Intra-uterine device; Contraceptive injection (prolonged-release gestagen); Subdermal implantation;Vaginal ring or Transdermal patch). 3. Body mass index ≥ 18.5 and \< 32 kg/m2. 4. Normal sleep habits, i.e. usual self-reported total sleep time \> 6 h; usual self-reported time to fall asleep \< 30 min; usual bedtime between 10:30 pm and 01:00 am. 5. Subject is in good health as determined by a medical history, physical examination and ECG. 6. Negative any use of illicit drug, alcohol (ethanol), stimulants. Exclusion Criteria: 1. Any use of medications within 1 month prior to screening visit, except for contraceptive pills. 2. Any sleep associated complains. 3. Previous exposure to Benzodiazepines and/or non-Benzodiazepine hypnotic drugs within 3 months prior to study initiation. 4. History of Epilepsy and or anti-epileptic drugs. 5. Excessive caffeine consumption (≥ 500 mg per day). 6. Pregnancy or breast feeding. 7. Night shift workers within 1 month prior to the screening visit. 8. Clinically relevant ECG abnormalities. 9. History of alcohol or drug abuse within 3 years prior to the screening visit. 10. Cognitive Behavioral Therapy (CBT) started within 1 month prior to the screening visit. 11. Known hypersensitivity to drugs of the same class as the study treatment, or any excipients of the drug formulation. 12. Treatment with another investigational drug within 1 month prior to the screening visit. 13. History of severe head injury.