Stroke Treatment With Acute Reperfusion and Simvastatin

Inclusion Criteria: * Patients older than 18 years acute ischemic stroke (less than 12 hours from stroke onset). * Stroke involving MCA-ACA-PCA. * NIHSS score 4 to 22. * Previous modified Rankin Scale score of 1 or 0. * Patient or proxy informed consent. * Patients not taking statins for the past six months. Exclusion Criteria: * Pregnancy or breastfeeding. * Clinical or radiological evidence on admission of intracranial hemorrhage, hemorrhagic infarction or tumor. * Seizures at the time of inclusion. * Complete or substantial recovery prior to randomization. * Patients with ipsilateral neurological deficit that may mask the evaluation of the current event. * Liver disease (AST or ALT more than twice upper normality limit). * Cardiogenic shock or relevant cardiac failure. * Patients with more than five times upper normality limit of CPK. * Myocardial infarction or any other thromboembolic event within the previous 30 days. * Active infection by the time of inclusion. * Documented hypersensibility to statins. * Drug abuse. * Expected short life-expectancy related to other systemic diseases.