Pharmacokinetic Interactions in Combination Treatment of Valproic Acid and Ertapenem in Normal Subjects

Inclusion Criteria: * Subjects who are healthy volunteers, men 19\~50 years * Subjects who have a weight more then 50kg and a condition ± 20% range of ideal weight Exclusion Criteria: * Subjects with evidence of clinically significant hepatic, pancreatic, renal, neurological, pulmonary, endocrine, blood tumor, psychiatric or cardiovascular disease * Subjects who have a GI disease (crohn's disease, etc.) that would increase the influence with absorbance medication or a GI surgery excluding appendectomy and hernia surgery * Subjects with uncontrolled hypotension (indicated by a sitting systolic blood pressure≤ 100 mmHg or diastolic blood pressure≤ 65 mmHg measured) and hypertension (indicated by a sitting systolic blood pressure≥ 150 mmHg or diastolic blood pressure≥ 95 mmHg measured) at vital sign measurement * Subjects with known allergy, hypersensitivity (anaphylaxis-type reaction; especially penicillin antibiotics) * Subjects with a history of drug abuse * Subjects who received certain medication (include oriental medicine) within the past 3 weeks or certain OTC-drug within 1 week * Subjects who participated in other clinical investigation within 2months prior to first administration Subjects who did whole blood donation (within 2months) or apheresis (within 1months) prior to first administration * Subjects who are chronic drinkers