Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia

University of Campinas, Brazil32 enrolled

Overview

This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Dental Anesthesia Efficacy

Interventions

PrilocaineDRUG

1.8mL infiltration of liposome-encapsulated 3% prilocaine, 3% plain prilocaine or 3% prilocaine with 0,03IU/mL felypressin in the buccal sulcus of the maxillary right canine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * good health * no history of allergy to the components of the local anesthetic formulations tested * maxillary canine, lateral incisor, and first premolar responsible to electric stimulation Exclusion Criteria: * intake of any medication that would alter pain perception * history of trauma or sensitivity, caries, restorations, periodontal disease and endodontic treatment in the maxillary canine, lateral incisor, and first premolar * systemic disease

Locations (1)

Piracicaba Dental School

Piracicaba, São Paulo, Brazil

Outcomes

Primary Outcomes

Anesthesia success, onset and duration of pulpal and gingival anesthesia.

Time frame: 10 minutes

Secondary Outcomes

Injection pain - Visual Analogue Scale

Time frame: 1 minute after the injections

Data from ClinicalTrials.gov

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