The Vitamin D Dose-Response Relationship

Bispebjerg Hospital55 enrolled

Overview

The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.

The work is addressing vitamin D production after UVB exposure and explore the importance of UVB dose and UV intensity. Four different UVB doses and four different UV intensities are used to explore these relationships. Many assumptions have been made concerning the vitamin D production after UVB exposure but only few studies exist.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Vitamin D Status

Interventions

UVBRADIATION

0.375 SED x 4 in a week

UVBRADIATION

0.75 SED x 4 in a week

UVBRADIATION

1.5 SED x 4 in a week

UVBRADIATION

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 years * Healthy Exclusion Criteria: * Sun bed use * Holiday or business travel south of 45 degrees latitude during trial * Illness * Drug addiction * Pregnancy * Lactating

Locations (1)

Bispebjerg Hospital, Department of Dermatology

Copenhagen NV, NV, Denmark

Outcomes

Primary Outcomes

Vitamin D (nmol/l)

Vitamin D measured in a blood sample to define the dose-response relationship between UVB dose, UV intensity and Vitamin D production in the skin after UVB exposure.

Time frame: 2 days after exposure

Secondary Outcomes

Other parameters

To invesitage whether other parameters like sex, BMI, Diet etc. influences the vitamin D production after UVB exposure.

Time frame: 2 days after radiation

Data from ClinicalTrials.gov

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