Contrast Enhanced Ultrasonography (CEUS) of Patients With Crohn's Disease

Haukeland University Hospital20 enrolled

Overview

The purpose of this study is investigate if high frequency sonography and contrast enhanced sonography can be used to predict remission in patients with deterioration of Crohn's disease treated with steroids or tumor necrosis factor (TNF) alfa inhibitors.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Crohn's Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Deterioration of Crohn's disease * CDAI\>150 * Treated with systemic steroids or TNF alfa inhibitors * Lesion found on ultrasound Exclusion Criteria: * Disease location not reachable with ileocolonoscopy * Pregnancy * Acute coronary disease * Unstable coronary disease * Previous allergic reaction to SonoVue or its components

Locations (1)

Department of Medicine, Haukeland University Hospital

Bergen, Hordaland, Norway

Outcomes

Primary Outcomes

Remission defined by Crohns disease activity index (CDAI)<150

Time frame: 52 weeks from inclusion

Secondary Outcomes

Surgical treatment for Crohn's disease during follow up. (Surgery for perianal disease not included.)

Time frame: 52 weeks

Mucosal healing on ileocolonoscopy. Defined by Simple Endoscopic Index for Crohn's disease (SES-CD)

Time frame: 12 weeks

Data from ClinicalTrials.gov

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