Efficacy of Two Antiemetic Regimens in Patients Receiving Radiotherapy and Concomitant Weekly Cisplatin

Inclusion Criteria: (abbreviated) 1. The patient has a diagnosis cervical cancer. 2. The patient understands the nature and purpose of this study and the study procedures and has signed informed consent. 3. The patient is aged \> 18 years. 4. The patient must be both chemo- and radiotherapy (RT) naïve. NB: previously low voltage RT or electron RT for non-melanoma skin cancers is allowed. 5. The patient is scheduled to receive fractionated radiotherapy and concomitant weekly cisplatin at a dose of ≥ 40 mg/m2 for at least five weeks. 6. Brachy therapy is scheduled to be initiated after the third cycle of weekly cisplatin, and preferentially after the fifth week of treatment. 7. Chemotherapy with an emetic risk potential of minimal or mild (up to 30%) is allowed on days 1-4 (see ref. 14). 8. The patient has a WHO Performance Status of ≤ 2. Exclusion Criteria: (abbreviated) 1. The patient has a current malignant diagnosis other than cervical cancer, with exception of non-melanoma skin cancers. 2. The patient is aged \< 18 years. 3. The patient is scheduled to receive less than five weeks of fractionated radiotherapy and concomitant weekly cisplatin. 4. Brachy therapy is planned to be initiated before the third cycle of weekly cisplatin. 5. The patient has been previously treated with radiotherapy, and/or chemotherapy, with exception of treatment with low voltage RT or electron RT for non-melanoma skin cancers . 6. The patient has a WHO Performance Status of \> 2.