Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

University Hospital, Geneva13 enrolled

Overview

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Non Invasive Ventilation Patient Ventilator Interaction

Interventions

Neurally Adjusted Ventilatory AssistDEVICE

Non invasive ventilation under Neurally adjusted Ventilatory Assist

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin Exclusion Criteria: * severe hypoxemia requiring an FIO2\>0.6 * hemodynamic instability * known oesophageal problem * active upper gastro-intestinal bleeding * any other contraindication to the insertion of a naso-gastric tube * impaired consciousness or absence of patient cooperation * facial or laryngeal lesions contraindicating the use of NIV * poor short term prognosis

Locations (4)

St Luc University hospital

Brussels, Belgium

Bernard Lambermont

Liège, Belgium

HUG, University Hospital

Geneva, Switzerland

CHUV University hospital of Lausanne

Lausanne, Switzerland

Outcomes

Primary Outcomes

Patient-ventilator synchronization parameters

Data from ClinicalTrials.gov

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