Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)

Inclusion Criteria: * Patient is a male or female who is undergoing primary unilateral surgery or the first surgery of a staged bilateral total knee replacement where the second stage will be at least 6 weeks later * Patient agrees to be blinded to their treatment group assignment * Patient is willing and able to return for follow-up over at least a six (6) month post-operative period although longer follow-up may be desired * Patient agrees to participate by signing an IRB approved Informed Consent Form Exclusion Criteria: * Patient will have a staged bilateral total knee replacement with the second stage to be performed less than 6 weeks after the first stage surgery PRP in * Patient has had previous surgery on the operative knee that will necessitate the removal of existing hardware (e.g. previous osteotomy) * Patient has a known adverse reaction or sensitivity to bovine (cow) thrombin (used as part of the platelet rich plasma system) or other bovine-derived products * Patient has hemoglobin \< 12.0 (males), \< 11.0 (females) * Patient has a clinically significant anxiety disorder * Patient is on therapeutic anticoagulation medication and has an INR \> 1.3 * Patient has a severe bleeding disorder * Patient has a known addiction to drugs or alcohol, including, but not limited to: chronic daily use of narcotic medications for more than 90 days prior to surgery * Patient is pregnant * Patient is a prisoner * Patient is involved in a personal litigation (e.g. Worker's Compensation) that relates to their knee surgery * Patient is actively participating in another medical device, drug, or biologic clinical trial (active defined as having treatment within the last 30 days)