The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

Queen Mary University of London

Overview

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Conditions

Ischaemia-reperfusion (IR) Injury

Interventions

C-type natriuretic peptide (CNP)DRUG

360 pmol/min for 15 minutes intra-arterially

SalineDRUG

Sodium Chloride 0.9% intra-arterially 0.5ml/min

AcetylcholineDRUG

2 stepped infusions for a total 9min per limb, totalling 1.05micromoles per limb

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill Exclusion Criteria: * History of medical illness * Unwillingness to sign consent form * Use of non-OCP medications * Hypertension on examination of the blood pressure

Locations (1)

Queen Mary University London

London, United Kingdom

Outcomes

Primary Outcomes

Change in area under curve dose-response to acetylcholine after IR injury

Time frame: 2h

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.