Value of Functional Anesthetic and Provocative Discography in the Surgical Treatment of Discogenic Pain

Northwestern University

Overview

Although discography and spinal imaging techniques, either alone or in combination, are commonly used to diagnose discogenic pain, their exact role in predicting surgical results are poorly defined. Our aim in this study is to compare the ability of Functional anesthetic discography (FAD), and Provocative Discography (PD) to diagnose discogenic pain and to correctly identify the disc levels for the surgical treatment. Proper identification for disc levels should improve the overall results of surgery for this condition. Patients with discogenic pain have better outcomes if the disc levels for the fusion surgery are identified by using FAD compared to similar disc level identification by PD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Conditions

Discogenic Pain Low Back Pain

Interventions

Functional anesthetic discographyPROCEDURE

Functional anesthetic discography will be performed to diagnose discogenic pain and to correctly identify the disc levels for the surgical treatment. Proper identification for disc levels should improve the overall results of surgery for this condition.

Provocative DiscographyPROCEDURE

Provocative Discography will be performed to diagnose discogenic pain and to correctly identify the disc levels for the surgical treatment. Proper identification for disc levels should improve the overall results of surgery for this condition.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 21 to 65 years. 2. Symptoms of at least 6 months duration. 3. Primarily axial low back pain. 4. At least 6 months of conservative treatment, including, physical therapy, injections, chiropractic etc. 5. Patients with overall pain scores of greater than 6/10 (NRS). 6. Recent (within the past 6 months) lumbar spine MRI showing: disc desiccation and loss of disc height of at least one disc level. Exclusion Criteria: 1. History of previous spine surgery. 2. MRI changes at more than two disc levels on the recent (within the past 6 months) lumbar spine MRI. 3. Clinical or radiological evidence of significant: 1. Disc herniation 2. Spinal Stenosis 3. Spinal Deformity 4. Spondylolisthesis 5. Spinal instability or pars-defect 6. Facet Syndrome 7. Sacroiliac Joint Dysfunction 8. Myofascial Pain Syndrome 9. Fibromyalgia 4. Current issues of: 1. Litigation 2. Disability 3. Drug addiction or substance abuse 4. Chronic pain medication abuse 5. Current diagnosis of and medication use for unstable anxiety, depression, and/or behavioral disorders.

Outcomes

Primary Outcomes

Pain

Numerical Rating Scale (11-point numerical rating, 0-10, scale of pain intensity) Standard Morphine Equivalent intake

Time frame: One Year

Secondary Outcomes

Physical functioning

Oswestry Disability Index

Time frame: One Year

Quality of Life

SF-36 health survey

Time frame: One Year

Patient Satisfaction

Patient Global Impression of Change

Time frame: One Year

Data from ClinicalTrials.gov

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