Hepa Wash Treatment of Patients With Hepatic Dysfunction in Intensive Care Units

Inclusion Criteria: 1. Bilirubin ≥ 2 mg/dl AND 2. SOFA-score ≥ 9 calculated 12 hours after initiating medical resuscitation measures AND 3. Patient is in the intensive care unit AND 4. Signed informed consent of the patient or legal representative AND 5. Patients are 18 years or older AND 6. Enrollment of patients within 96 hours of fulfilling inclusion criteria (1-3). Exclusion Criteria: 1. Patient with known history of chronic liver disease 2. Untreatable extrahepatic cholestasis 3. Patient has a survival prognosis of less than 6 weeks because of a chronic disease (e.g. metastasizing cancer) and before the acute event which lead to the ICU admission. 4. PaO2/FIO2 ≤ 100 mmHg 5. Patients on kidney dialysis 6. Patients with MELD-score of 40 7. Mean arterial pressure ≤ 50 mmHg despite conventional medical treatment 8. Patient testament excludes the use of life-prolonging measures 9. Post-operative patients whose liver failure is related to liver surgery 10. Uncontrolled seizures 11. Active or uncontrolled bleeding 12. Weight ≥ 120 kg 13. Pregnancy 14. Patient diagnosed with Creutzfeldt-Jakob disease 15. Participation in another clinical study