Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.

Inclusion Criteria: * Patients aged from 18 to 70 years * Written informed consent * One of the following three criteria: * Recently diagnosed IgG or IgA monoclonal gammopathy without clinical or biological features of malignant hemopathy * IgG or IgA MGUS regardless the date of the diagnosis * SMM regardless the date of the diagnosis * Normal blood count, creatininemia and calcemia \* * Bence-Jones proteinuria below 1g/24 hours * Absence of bone pain * No clinical or biological features of amyloidosis * No recurrent episode of infection (more than 2 infections requiring antibiotics in the previous 6 months) \* In case of abnormal blood count, renal failure or hypercalcemia, patients may be included if an intercurrent cause is identified (for example anemia associated with iron deficiency) Diagnostic criteria for MGUS: * Monoclonal component concentration below 30 g / l AND * Bone marrow plasmacytosis below 10% * Bence-Jones proteinuria below 1g/24 hours * Normal blood count, creatininemia and calcemia \* * Absence of bone lesions on conventional bone radiographies * No clinical or biological features of amyloidosis * Absence of hyperviscosity syndrome * No recurrent episode of infection (more than 2 infections requiring antibiotics in the previous 6 months) \* In case of abnormal blood count, renal failure or hypercalcemia, patients may be included if an intercurrent cause is identified (for example anemia associated with iron deficiency) Diagnostic criteria for SMM: * Monoclonal component concentration greater than 30 g / l AND / OR * Bone marrow plasmacytosis greater than 10% * Bence-Jones proteinuria below 1g/24 hours * Normal blood count, creatininemia and calcemia \* * Absence of bone lesions on conventional bone radiographies * No clinical or biological features of amyloidosis * Absence of hyperviscosity syndrome * No recurrent episode of infection (more than 2 infections requiring antibiotics in the previous 6 months) \* In case of abnormal blood count, renal failure or hypercalcemia, patients may be included if an intercurrent cause is identified (for example anemia associated with iron deficiency) Exclusion Criteria: * Patients younger than 18 years * Patients older than 71 years * IgM monoclonal gammopathy (regardless of diagnosis) * Monoclonal gammopathy associated with hematologic malignancies (multiple myeloma, chronic lymphocytic leukemia, ...) * Patients with chronic liver disease, autoimmune or neoplastic disease for less than 5 years * Active viral hepatitis B or C * HIV seropositive patient * Pregnant woman * Breastfeeding woman