RFS (Radiofrequency Stylet) - Radiofrequency Perforator Vein Treatment Study

Inclusion Criteria: * Male and female, ages 18 to 80 years, from all racial and ethnic origin * Have the ability to understand the requirements of the study, provide written informed consent to participate, and agree to abide by the study requirements * Available for all the follow-up visits and in a physical condition allowing ambulation after the procedure * Incompetent GSV and/or SSV in the target limb has been treated at least 3 months before study enrollment or competent GSV and SSV at time of treatment * CEAP 4 - 6 classification * DUS reflux of ≥0.35 sec or more of the target IPV and/or an intra-fascia diameter of ≥0.3 mm Exclusion Criteria: * Acute (at Screening) superficial venous thrombosis of either limb * Acute (within the prior 3 months) deep venous thrombosis or phlebitis in either limb * Complete or near complete deep venous obstruction documented by ultrasound * Previously participated in any study involving ClosureRFS * Actively participated in any other investigational study within 30 days of enrollment into this study * Pregnant at the time of treatment. Status verified by pregnancy test via blood or urine for women ≤ 55 years old. * Having a medical condition, serious intercurrent illness, or extenuating circumstance that would significantly decrease study compliance, including all required study follow-up * Have any condition that, in the opinion of the Investigator, would jeopardize the safety of the patient or affect the validity of the trial results * Have a history of excessive alcohol consumption or any use of illegal drugs rendering the patient unreliable, or at risk during this trial * Have undergone major surgery which may result in abnormalities of the target body area, reasonably suspected to compromise the study outcomes * Have undergone an invasive procedure of the target body area (e.g., needle biopsy or surgical procedure) within 30 days of enrollment into this study * Known incompatibility, such as an allergic reaction to anesthetics to be used in the incompetent perforator vein treatment * Patients requiring hyperbaric therapy involving the treated limb during the 6 month post treatment follow-up period * Great toe pressure measurement of ≤ 70 mmHg * CEAP 6 classified patients receiving high dose steroid medication or the following medications that interfere with normal mechanisms of wound healing, e.g. glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), anti-neoplastic and immunosuppressive drugs, and others like, colchicine and penicillamine. * Expressing a body mass index (BMI) of ≥ 35.