Evaluation of a Noninvasive Diabetes Screening Device in Subjects at Risk for Diabetes

Inclusion Criteria: 1. Age greater than or equal to 45 years; OR 2. Age 18 to 44 years and a BMI \> 25 kg/m² with one or more of the following risk factors: * Elevated waist circumference, \> 35 inches for women and \>40 inches for men * Habitually physically inactive (does not exercise regularly) * Has a first-degree relative with diabetes * African American, Latino, Native American, Asian American, Pacific Islander * Has delivered a baby weighing \> 9 lb or diagnosed with gestational diabetes * Hypertension (≥130/≥ 85 mmHg) or being treated for hypertension * HDL cholesterol level \< 35 mg/dL and/or a fasting triglyceride level ≥ 250 mg/dL or being treated for dyslipidemia with medication * Has been previously diagnosed with Polycystic Ovary Syndrome (PCOS) * Had impaired glucose tolerance or impaired fasting glucose on previous testing within the last 3 yrs * Conditions associated with insulin resistance such as acanthosis nigricans * History of vascular disease including heart attack, stroke, angina, coronary heart disease, atherosclerosis, congestive heart failure or peripheral arterial disease Exclusion Criteria: * Prior participation in VL-2701 * Receiving investigational treatments in the past 14 days * Psychosocial issues that interfere with an ability to follow study procedures * Conditions that cause secondary diabetes including Cushing's syndrome, acromegaly, hemochromatosis, pancreatitis, or cystic fibrosis * Diagnosed with any type of diabetes, including type 1 or 2 * Taking glucose lowering medications * Known to be pregnant * Receiving dialysis or having known renal compromise * Scars, tattoos, rashes or other disruption/discoloration on the left volar forearm. * Recent (within past month) or current oral steroid therapy or topical steroids applied to the left forearm; inhaled steroid therapy is not excluded Current chemotherapy, or chemotherapy within the past 12 months * Receiving medications that fluoresce * Known to have, or at risk for, photosensitivity reactions ( e.g., sensitive to ultraviolet light, or taking medication known to cause photosensitivity) * Prior bariatric surgery