A new notion"Fast Track Multi-Discipline Treatment" for colorectal cancer is thought with several benefits such as shorter hospitalization stay and less costs. This randomized study aims to compare the differences between conventional and Fast Track Multi-Discipline Treatment for colorectal cancer in hospitalization day, complications, costs and quality of life.
Laparoscopic Surgery, Fast Track Treatment and XELOX Chemotherapy have been introduced in the treatment of colorectal cancer. All of these procedures are contributed to reduce the hospitalization stay. However, the most economical mode for combination of these procedures is still unclear. This is a randomized controlled study, a new notion"Fast Track Multi-Discipline Treatment" is proposed, which is the combination of the Laparoscopic Surgery, Fast track perioperative treatment during perioperative period and XELOX Chemotherapy. The purpose of this study is to compare the Fast Track Multi-Discipline Treatment with the conventional treatment(Open Surgery with conventional treatment during perioperative period and mFolfox6 chemotherapy) for colorectal cancer on several aspects like the average hospitalization day, complications, costs and quality of life.The focus of the study will be to investigate whether the Fast Track Multi-Discipline Treatment reduces hospital stay with similar complications compared with conventional perioperative treatment. Moreover, the trial will clarify whether laparoscopic surgery is essential for Fast Track Multi-Discipline Treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
374
Laparoscopic surgery for colorectal cancer using STORZ laparoscope
XELOX chemotherapy
Conventional (mFolfox6) chemotherapy
Fast track treatment during perioperation period
Conventional treatment during perioperation period
Open surgery for colorectal cancer using conventional methods
Second Affiliated Hospital Zhejiang University College of Medicine
Hangzhou, Zhejiang, China
People's Hospital of Shaoxing
Shaoxing, Zhejiang, China
hospitalization day
The overall hospitalization stay during treatment from the first day in hospital to leave hospital when finish adjuvant chemotherapy or surgery (for patients who don't need chemotherapy).
Time frame: 6-month post surgery
surgical complications
Surgical complications include injury of ureter, intraoperative transfusion, infection of incision and anastomotic leakage etc.
Time frame: 3-month post surgery
chemotherapy related adverse event
Chemotherapy related adverse event, according to NCI CTCAE Version 3.0, include nausea, vomit, diarrhea and neutropenia etc.
Time frame: 6-month post surgery
quality of life
Quality of life will be measured by EORTC QLQ-C30 and QLQ-CR38 questionaire.
Time frame: preoperation, 3-month post surgery and 6-month post surgery
hospitalization costs
The overall hospitalization costs from the first day in hospital to day that adjuvant chemotherapy finished.
Time frame: 6-month post surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.