Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation

Seoul National University Hospital96 enrolled

Overview

Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Hypotension After Reperfusion in Liver Transplantation

Interventions

phenylephrineDRUG

100 mcg of phenylephrine (volume 10 ml) iv at the time of reperfusion

epinephrineDRUG

10mcg of epinephrine (volume 10 ml) is administered iv at the time of reperfusion

placebo controlDRUG

10ml of normal saline is administered at the time of reperfusion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- adults scheduled to undergo liver transplantation Exclusion Criteria: \- pediatric liver transplantation

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Occurrence of Postreperfusion Syndrome (PRS)

the number of patients who showed PRS (hypotension defined as \< 30% of baseline mean arterial pressure \[MAP\] lasting over 1 min immediately after reperfusion of liver graft) was divided by the total number of patients enrolled for each group

Time frame: immediately after reperfusion

Data from ClinicalTrials.gov

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