Intracoronary bolus Abciximab single is non-inferior to intravenous and continuous 12- hours infusion in the size reduction of infarction on cardiac magnetic resonance in Non-ST elevation Myocardial infarction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
patients intracoronary bolus only group and intravenous bolus and 12-hours continuous infusion group bolus:0.25mg/kg body weight,continus 12hrs-0.125ug/kg per minute(maximum: 10ug/min)
Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital
Seoul, South Korea
RECRUITINGIn cardiac MRI- infarct size (total late enhancement volume at day 3-7)
MRI: magnetic resonance image
Time frame: day 3~7 after percutaneous coronary intervention
in-hospital and after 1-months:the major adverse cardiovascular events : death, myocardial infarction, hospitalization for heart failure, myocardial ischemia, etc.
Time frame: 1 month
b. major bleeding : Hemoglobin 4 or more reduction, 2-unit If you need more than two RBC transfusions, intracranial or retroperitoneal bleeding, urgent operation for bleeding complication.
RBC: red blood cell
Time frame: 1 month
TIMI III flow count /myocardial blush score after PCI
TIMI: thrombolysis in myocardial infarction PCI: percutaneous coronary intervention
Time frame: 1 day
At cardiac MRI : LV ejection fraction,LV end-systolic volume,LV end diastolic volume,regional wall motion score index
LV: left ventricle
Time frame: 1 week
Discharge, 1- month after comparing NT-proBNP
NT-proBNP : N-terminal pro-B-Type natriuretic peptide
Time frame: 1 month
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