Influence of Drug-drug Interactions on the Pharmacokinetics (PK) of Voriconazole

Inclusion Criteria: * 1.Healthy male subjects aged 20 - 50 years. * 2.A body mass index (BMI) in the range 17-28 kg/m2. * 3.Sufficient ability to understand the nature of the study and any hazards of participating in it. Provide written informed consent after being fully informed about the study procedures. Exclusion Criteria: * 1.Presence or history of severe adverse reaction to any drug or a history of severe allergic disease. * 2.Clinically relevant abnormal medical history that could interfere with the objectives of the study. * 3.Presence or history of eye disease or eye field defect. * 4.A subject with history of gastrointestinal disease or surgery (except simple appendectomy or repair of hernia), which can influence the absorption of the study drug. * 5.A subject whose liver function test (AST, ALT, GGT, ALP, LDH) result is over 1.25 times of upper limit of normal range. * 6.A subject whose SBP is over 140 mmHg or below 90 mmHg and DBP is over 100 mmHg or below 50 mmHg. * 7.Presence or history of drug abuse. * 8.Participation in other clinical trial within 2 months. * 9.Use of a prescription medicine, herbal medicine within 2 weeks or over-the-counter medication within 1 week before first dose. * 10.Blood donation during 2 months or apheresis during 1 month before the study. * 11.Presence or history of alcohol abuse. * 12.Smoking of more than 10 cigarettes/day. * 13.Use of grapefruit juice, xanthine containing beverage, alcohol or smoking during restriction period. * 14.Subject judged not eligible for study participation by investigator.