rTMS for Motor and Mood Symptoms of Parkinson's Disease

Inclusion Criteria: * Diagnosis of PD according to the UK Brain Bank Criteria, confirmed by a neurologist with expertise in movement disorders. * Minimum of 3 years since the formal diagnosis of PD, and requiring dopaminergic therapy (at a minimum, on levodopa and/or dopamine agonist therapy). * Minimum baseline OFF score on the motor UPDRS of 15 points of more. * Lack of features suggestive of atypical parkinsonism, such as early prominent cerebellar, pyramidal, or autonomic dysfunction; supranuclear gaze palsy; falls within the first year of symptoms; hallucinations prior to initiating a dopaminergic agent. * No history of neuroleptics or other drugs that induce parkinsonism in the past 60 days. * Currently optimally treated with medications and, in the view of the treating neurologist, will unlikely be requiring anti-PD medication adjustments in the next 6 months. * On a stable dose of all medications for 30 days (except anti-depressants- which should be stable for at least 90 days). * Lack of dementia such that, in the view of the enrolling investigator, the patient is able to give proper informed consent. In addition, all patients must score at least a 26 out of 30 on the screening MMSE. * HAM-D score \> 12 on the first 17 questions of the scale, despite the current use of antidepressant(s) for at least 90 days, or documentation of adequate trial of antidepressants (i.e. at least 6 weeks on an optimal dose), or documentation of intolerability to antidepressants. * Untreated depression or on a stable dose of antidepressants for 90 days (untreated patients need to have tried at least one antidepressant in the past). * Age 21 years or older. * Patient meets the criteria for a depressive disorder based on either the MINI interview (major depression) or SCID (minor depression, or dysthymia). Exclusion Criteria: * Intracranial metallic bodies (e.g. from prior neurosurgical procedure). * Signs or symptoms of increased intracranial pressure. * Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt. * History of seizures or unexplained loss of consciousness. * Possible pregnancy. * Family history of medication refractory epilepsy. * History of substance abuse within the last 6 months. * History of known structural brain abnormality. * History of exposure to repetitive TMS in the past (to minimizing risk of unblinding sham condition). * History of exposure to ECT in the past. * Patients with suicidal ideation deemed by the investigator to be significant enough to render the individual a suicidal risk. * Patients with a history of hospitalization for suicidal ideation/attempts. * Patients requiring hospitalization for their depression within the past six months will not be allowed in the study. If a participating subject's depression worsens during the study to a degree that hospitalization is deemed necessary, or if the subject develops significant suicidal ideation, he/she will be withdrawn from the study and referred to a psychiatrist for treatment. * Patients with bipolar affective disorder and those whose depression is characterized by psychotic features. * Patients with a history of spontaneous hallucinations or delusions as well as those with other underlying psychotic disorders (e.g., schizophrenia, schizoaffective disorder, delusional disorder). The presence of visual illusions or hallucinations deemed by the enrolling physician to be clearly related to antiparkinsonian medications will be allowed but only if the enrolling physician believes that they are stable and unlikely to require changes in medication (i.e., addition of an antipsychotic or reduction in antiparkinsonian drug dosage). Patients with delusions will be excluded. * Subjects judged by the clinician investigator to have dementia (by DSM-IV and MMSE criteria) will be excluded. * Subjects judged by the clinician investigator to have dementia (by MoCA criteria) will be excluded. * Subjects with unstable medical condition such as diabetes, cardiac disease, and hypertension. * Subjects with brittle or severe motor fluctuation that will cause severe discomfort during OFF medication testing at Baseline, immediately post-TMS, and at Months 1, 3, and 6. * Excessive alcohol use or taking one of the following exclusionary medications: Imipramine, Amitriptyline, Doxepin, Nortriptyline, Maprotiline, Chlorpromazine, Clozapine, Foscarnet, Ganciclovir, Ritonavir, Amphetamines (MDMA, ecstasy), cocaine, phencyclidine (PCP, angel's dust), ketamine, gamma-hydroxybutyrate (GHB), theophylline, and haloperidol.