PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

Inclusion Criteria: 1. Age between 21 and 80 years old 2. Physically healthy, stable weight 3. Requiring unilateral total knee arthroplasty (TKA) 4. Subject exhibits preoperative radiographic evidence of joint degeneration consistent with TKA that cannot be treated in non-operative fashion 5. Subject has severe knee pain and disability due to degenerative joint disease 6. Subject must understand the nature of the procedure and provide written informed consent prior to the procedure. 7. Subject must be willing and able to comply with all follow-up evaluations 8. Subject must be willing to undergo TKA using the Signature Knee System Exclusion Criteria: 1. Age younger than 21 or greater than 80 years old 2. Previous history of infection in the affected joint 3. Peripheral vascular disease 4. Revision procedures 5. BMI \> 35 6. Valgus or varus deformity \> 15 degrees 7. Flexion contracture \> 15 degrees 8. History of diabetes 9. Anticoagulation therapy which cannot be discontinued 10. Cognitive impairment or mental illness 11. Severe cardiopulmonary deficiencies 12. Known coagulopathy 13. Immunocompromised 14. Kidney disease (any type) 15. Unable to follow instructions or complete follow-up 16. Currently taking any medication known to affect healing 17. Currently enrolled in another investigational device or drug trial