Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers

University Hospital, Grenoble20 enrolled

Overview

The purpose of this study is to test whether prostacyclin analogues' cathodal iontophoresis induce a cutaneous vasodilation in healthy volunteers's forearm, without local side effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

treprostinilDRUG

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

iloprostDRUG

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

NaCl 0.9%DRUG

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers * age above 18 Exclusion Criteria: * any chronic disease * any drug intake

Locations (1)

Unité de Pharmacologie Clinique, Inserm CIC3, CHU Grenoble

Grenoble, France

Outcomes

Primary Outcomes

Amplitude of forearm cutaneous vasodilatation assessed using laser Doppler imaging

Time frame: 24 hours

Secondary Outcomes

Local tolerance assessed clinically

Time frame: Day 0 and after 7 days

Data from ClinicalTrials.gov

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