Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.

Hospices Civils de Lyon90 enrolled

Overview

The use of paravertebral catheters is a recommended technique to achieve postoperative analgesia after thoracic surgery. To date there is no consensus on which drug regime (local anesthetics with or without opioid) is best. The aim of this prospective clinical trial is to determine wether the use of ropivacaine and sufentanil injected through a thoracic paravertebral catheter results in decreased acute postoperative pain compared with plain ropivacaine in patients after thoracoscopic lung surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Pain, Postoperative

Interventions

Ropivacaine + SufentanilDRUG

Sufentanil at 0.25 µg/ml added to ropivacaine at 2 mg/ml at a perfusion rate of 0.15 ml/kg/h for continuous paravertebral block over 48 hours

RopivacaineDRUG

Ropivacaine at 2 mg/ml at a perfusion rate of 0.15 ml/kg/h for continuous paravertebral block over 48 hours

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient scheduled for planned video-assisted thoracic surgery * Patient that consent to participate * Planned placement of paravertebral catheter * Patient having a medical insurance Exclusion Criteria: * Patient less than 18 years * Refusal to participate * Known pregnancy * Known allergies to local anesthetics, sufentanil and /or to iodinated contrast material * Intolerance to sufentanil and/or morphine * Chronic consumption of opiates * Preoperative chronic pain syndrome * Patient having a contraindication to placement of paravertebrtal catheter

Locations (1)

Hospices Civils de Lyon, Hopital Louis Pradel, Department of Anesthesiology

Bron, France

Outcomes

Primary Outcomes

morphine consumption during the first 48 hours

Time frame: 48 hours

Secondary Outcomes

Acute pain

using the Visual Analogue Scale (VAS) score

Time frame: 48 hours

Biological measurements

Oxygen saturation, level of sedation, respiratory rate, nausea, vomiting, itching, urine retention, blood pressure, heart rate

Time frame: 48 hours

Patient satisfaction

Time frame: 48 hours

Chronic pain

assessed with the Saint-Antoine Pain Questionnaire (French version of the Mac Gill Pain Questionnaire) and the DN4 questionnaire.

Time frame: 3 and 6 monthes

Data from ClinicalTrials.gov

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