The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms. It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses. This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.
Study Type
OBSERVATIONAL
Enrollment
28
Charité - Universitätsmedizin Berlin
Berlin, Germany
autoantigen-specific T-cells in patients with acute media infarct
quantitative determination of autoantigen-specific T-cells in patients with acute media infarct
Time frame: within 36 h
leukocytes in patients with acute media infarct
quantitative and qualitative analysis of leukocytes in patients with acute media infarct
Time frame: within 36 hours
frequency and phenotype of CNS-autoreactive immune cells under the influence of immunodepression
Time frame: within 36 h, after day 3, 7, 90 and 180
clinical course, i.e. mortality and prognosis (measured by mod. Rankin Scale)
Time frame: after day 90 and 180
clinical course, i.e. mortality and prognosis (measured by Bartel Index)
Time frame: after day 90 and 180
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