Evaluation of the Safety and Immune Response to an Investigational Dengue Type 1 Vaccine

Inclusion Criteria: * In good general health as determined by physical examination, laboratory screening, and review of medical history * Available for the duration of the study, including approximately 6 weeks post-vaccination * Female participants of childbearing potential must be willing to use effective contraception for the duration of the trial Exclusion Criteria: * Currently breast-feeding or pregnant * Exhibits evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies * Presence of a behavioral, cognitive, or psychiatric disease that affects the ability of the participant to understand and cooperate with the requirements of the study protocol * Has screening laboratory values of Grade 1 or above for absolute neutrophil count (ANC), ALT, and serum creatinine, as defined in this protocol * Presence of any condition that would jeopardize the safety or rights of the participant or would render the participant unable to comply with the protocol * Significant alcohol or drug abuse in the past 12 months which has caused medical, occupational, or family problems, as indicated by participant history * History of a severe allergic reaction or anaphylaxis * Severe asthma (emergency room visit or hospitalization within the last 6 months) * Presence of HIV infection, determined by screening and confirmatory assays * Presence of hepatitis C virus (HCV) infection, determined by screening and confirmatory assays * Presence of hepatitis B virus (HBV) infection, determined by hepatitis B surface antigen (HBsAg) screening * Presence of any known immunodeficiency syndrome * Uses anticoagulant medications * Has used corticosteroids (excluding topical or nasal) or immunosuppressive drugs within 42 days prior to or following vaccination. An immunosuppressive dose of corticosteroids is defined as greater than or equal to 10 mg prednisone equivalent per day for greater than or equal to 14 days. * Has received a live vaccine within 28 days or a killed vaccine within 14 days prior to vaccination or anticipated receipt of any vaccine during the 42 days following vaccination * Has no spleen * Received blood products within the past 6 months, including transfusions or immunoglobulin or anticipated receipt of any blood products or immunoglobulin during the 42 days following vaccination * History or serologic evidence of previous dengue virus infection or other flavivirus infection (e.g., yellow fever virus, St. Louis encephalitis, West Nile virus) * Has received a flavivirus vaccine (licensed or experimental) * Anticipates receipt of any investigational agent in the 42 days before or after vaccination * Participant has definite plans to travel to a dengue endemic area during the study