A clinical trial to determine the effectiveness and safety of AUY922 compared to other drugs known to be effective against gastric cancer in second line therapy for patients who have failed one line of chemotherapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
68
Progression Free Survival
Time frame: 21 day cycle: treatment until death, lost to follow up or withdrawal
Estimate of the Overall Survival Treatment Effect to see if there is a difference in treatment effect in patients who receive AUY922 versus patients who receive comparator medications.
Time frame: 21 day cycle: treatment until death, lost to follow up or withdrawal
Objective Response Rate to see if there is a difference in treatment effect in patients who receive AUY922 versus patients who receive comparator medications.
Time frame: 21 day cycle: treatment until death, lost to follow up or withdrawal
Evaluate Safety by measuring cardiac safety, recording Adverse Events (AEs) and tracking the tolerability of AUY922
Time frame: 21 day cycle: treatment until death, lost to follow up or withdrawal
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USC/Kenneth Norris Comprehensive Cancer Center USC/Norris
Los Angeles, California, United States
University of California at Los Angeles Dept. of UCLA (4)
Los Angeles, California, United States
Horizon Oncology Center
Lafayette, Indiana, United States
The Sidney Kimmel Cancer Center at Johns Hopkins Hospital Dept. of SKCC @ JHU
Baltimore, Maryland, United States
Clinical Research Alliance Dept.ofArenaOncologyAssoc(2)
Lake Success, New York, United States
Baylor Health Care System/Sammons Cancer Center Baylor Texas Oncology
Dallas, Texas, United States
Tyler Cancer Center Dept.ofTylerCancerCtr. (2)
Tyler, Texas, United States
Novartis Investigative Site
Adelaide, South Australia, Australia
Novartis Investigative Site
Montreal, Quebec, Canada
Novartis Investigative Site
Bordeaux, France
...and 26 more locations