Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients With Uremic Xerosis

Inclusion Criteria: * Patients of both sexes, of at least 10 years of age * Patients undergoing either hemodialysis or peritoneal dialysis due to chronic renal failure * Patients whose xerosis is related to their renal insufficiency status * Patients suffering from moderate to severe xerosis, i.e. with a severity score of at least 2, on two symmetric areas of the lower legs (Phase I test areas) * Patients who have not experienced phototherapy within 8 weeks prior to study entry * Patients with no antipruritic treatment, or with stable antipruritic treatments (e.g. antihistamines, cholestyramine, opioid inhibitors, charcoal) at least 4 weeks before study entry * Written informed consent (Appendix II) from the patients or parents Exclusion Criteria: * Patients under 10 years of age * Patients undergoing renal dialysis for another reason than MRD * Patients whose xerosis or pruritus is due to another reason than their MRD status * Patients suffering from mild xerosis (score £ 1) on the lower legs * Patients with xerosis of non comparable severity between the lower legs * Patients with a known history of allergy to one of the ingredients contained in the test product * Patient with an intercurrent condition which may interfere with a good conduct or the study parameters of the study * Patients treated with any other emollient/moisturizing topical preparation within the 7 days prior to study entry * Patients with phototherapy within 8 weeks prior to study entry * Patients who started an antipruritic treatment other than phototherapy, or who experienced unstable dosage schedule of antipruritic treatments (e.g. antihistamines, cholestyramin, opiod inhibitors, charcoal) within 4 weeks prior to study entry * Patients who participated in a study within the 3 months prior to study entry * Patients who are not able or willing to follow the study instructions * Patients or parents who refuse to give written informed consent