A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin

North Idaho Dermatology70 enrolled

Overview

The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Verruca Vulgaris

Interventions

Liquid nitrogen and cantharidinDRUG

Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterward.

Liquid nitrogen and topical placeboDRUG

Liquid nitrogen applied to wart(s), then placebo vehicle applied thereafter.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. common warts on non-genital, non-facial skin 2. otherwise healthy 3. between 18-65 and able to give informed consent 4. capable of tolerating treatment Exclusion Criteria: 1. Ill-health 2. Poor tolerance or sensitivity to treatments in study 3. \<18 years old; \>65 years old 4. verruca plana or condyloma acuminata 5. immunosuppression or immune dysfunction 6. significant peripheral vascular disease 7. significant sensitivity to cold 8. epidermodysplasia verruciformis 9. mosaiform warts or periungual warts

Locations (1)

North Idaho Dermatology

Coeur d'Alene, Idaho, United States

Outcomes

Primary Outcomes

Percentage of common warts cleared

Percentage of treated warts cleared with treatment, as measured with dermatoscopic examination, after 12 weeks.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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