Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome

Inclusion Criteria: * from 18yrs to 80 yrs , man and women * Minimal change disease is diagnosed by kidney biopsy * On screening, the patient shows that the level of urine protein/creatinine ratio is over 3.0 * On screening, the patient shows that the serum albumin is below 3.0g/dL * the patient sign on the concent form Exclusion Criteria: * the patient have experience to take tacrolimus or cyclosporin for 1 month * If it is the relapse of the nephrotic syndrome, before relapse, the maintenance dose of steroid is over 0.3 mg/kg/day * steroid dependent or steroid resistant or frequent relapse case * uncontrolled hypertension * pregnancy or anticipate pregnancy with 6 month * hypersensitivity to tacrolimus or macrolide * acute hepatitis or the level of AST or ALT is over 2 times of normal range or the level of bilirubin is over 2.0 mg/dL