The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery

Tehran University of Medical Sciences100 enrolled

Overview

Intravenous Tranexamic acid is used to reduce the hemorrhage during and after cesarean delivery in a double blind randomized placebo controlled trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

100

Conditions

Hemorrhage

Interventions

Tranexamic acidDRUG

Tranexamic acid in cases, normal saline in controls

Normal salineDRUG

Tranexamic acid in cases, normal saline in controls

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Term pregnancy 2. Single fetus 3. Maximally only one previous cesarean delivery Exclusion Criteria: 1. More than one previous cesarean delivery 2. Hx of other abdominal or pelvic surgery 3. Hx of medical disorders 4. Hx of thromboembolic disorders 5. Polyhydramnios 6. Macrosomia 7. Preeclampsia 8. Hx of sensitivity to Tranexamic acid 9. Abnormal Pt, PTT, PT or INR

Locations (1)

Laleh Eslamian

Tehran, Iran

Outcomes

Primary Outcomes

The Amount of Hemorrhage During Cesarean Delivery and Within 2 Hours Afterward

Time frame: During the procedure and within 2 hours afterwards

Secondary Outcomes

Amount of Hemorrhage in the First 24 Hour After Cesarean Delivery

Time frame: First 24 hours

Data from ClinicalTrials.gov

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