Impact of Spices and Herbs on Endothelial Function

Laval University224 enrolled

Overview

The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.

The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

224

Conditions

Endothelial Function

Interventions

CinnamonDIETARY_SUPPLEMENT

2.8g/day of cinnamon in capsules during 4 weeks.

OreganoDIETARY_SUPPLEMENT

2.8g/day of oregano in capsules during 4 weeks.

GingerDIETARY_SUPPLEMENT

2.8g/day of ginger in capsules during 4 weeks.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 40-70 yrs * Men and postmenopausal women * Waist girth \>102cm (men) or \>88cm (women) * LDL-C \> 2.8 mmol/L * Framingham 10-yr risk score \< 10% * Marginal endothelial dysfunction * Non smoker Exclusion Criteria: * Medication for lipid, hypertension, diabetes * History of CVD, diabetes, other endocrines disorders * Pre-menopausal women * Alcohol consumption \> 1 drink per day * Unusual dietary habits (e.g. vegetarism) * Chronic use of supplements (estrogens, vitamins, minerals or flavonoids) * Aversion or intolerance for spices and/or herbs * Injury to fingers or amrs that would interfere with endothelial function measurement

Locations (2)

Richardson Centre of Functional Foods and Nutracuticals

Winnipeg, Manitoba, Canada

Institute of Nutraceuticals and Functional Foods

Québec, Quebec, Canada

Outcomes

Primary Outcomes

Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone)

Time frame: at week 0 and week 4

Secondary Outcomes

Circulating level of plasma lipoproteins-lipids

Time frame: at week 0 and week 4

Oxidative stress

Time frame: at week 0 and week 4

Endothelial activation and inflammatory markers

Time frame: at week 0 and week 4

Data from ClinicalTrials.gov

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