Balloon Elution and Late Loss Optimization (BELLO) Study

Inclusion Criteria: * Age \> 18 years. * Patient providing written informed consent. * Patients with stable angina pectoris (Canadian Cardiovascular Society \[CCS\] 1, 2 3) or unstable angina pectoris with documented ischemia (CCS 4, Braunwald Class IB-C, IIB-C or IIIB-C), or patients with documented silent ischemia. * Patients who are eligible for coronary revascularization (angioplasty and/or CABG). * Female patients with child bearing potential must have a negative pregnancy test within one week before treatment and must use adequate contraception. Angiographic Inclusion Criteria: * Native coronary artery. * De novo lesion. * Reference vessel diameter \< 2.8mm by visual estimate. * Target lesion with a visually estimated stenosis \>50%. * Target lesion length \< 25mm by visual estimate. * A maximum of 2 epicardial vessels requiring revascularization. * A maximum of 2 target lesions can be included (In the case of treatment of more than one lesion, the treatment selected will remain the same). Exclusion Criteria: * Patients unable to give informed consent. * Patients enrolled in another study with any investigational drug or device within the past 30 days. * Patients scheduled for a major surgical intervention within 6 months of enrolment in the study. * Patients with acute (\< 24h) or recent (≤ 48 hours) myocardial infarction. * Patients with a contraindication to an emergency coronary bypass surgery. * Any individual who may refuse a blood transfusion. * Patients with serum creatinine \>2.0mg/dL or \>180umol/L. * Patients with severe congestive heart failure. * Patients who had a cerebral stroke \<6 months prior to the Index Procedure. * EF (Ejection Fraction) \< 30%. * Patients with any known allergy, hypersensitivity or intolerance to acetylsalicylic acid (ASA), Clopidogrel or Ticlopidine, Paclitaxel. * Any known allergy to contrast medium that cannot be pre-treated. Angiographic exclusion criteria: * \>2 epicardial vessels requiring revascularization. * Target lesion distance from the ostium of left anterior descending coronary artery (LAD)/left circumflex coronary artery (LCX)/right coronary artery (RCA) is \< 5 mm. * Target lesion is located in either a venous or arterial graft. * Target vessel contains a previously implanted stent. * Angiographic evidence of thrombus at the target site. * Chronic total occlusions. * Restenotic lesions. * Bifurcation lesions which the operator decides a 2-stent technique as intention-to-treat is required OR bifurcations with side branches ≥ 2.5mm. * Failure to successfully treat non-target lesions within the target vessel (non-target lesions must be treated prior the target lesion). * Greater than 2 non-target lesions treated during the index procedure. * Previous Percutaneous Coronary Intervention (PCI) within the last 3 months.