Phase I, Single Centre, Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043

Inclusion Criteria: * Pre-anaesthesia assessment judged without remarks by the investigator. * ASA physical status category 1 to 2 (up to and including 3 depending on applicable patient category) Exclusion Criteria: * Lack of a normal range of enzyme activity for BuChE * Known or suspected history of hypersensitivity to drugs with a similar chemical structure or class to AZD3043 (e.g., emulsion-based products like Diprivan,Intralipid), allergies to soybean or peanut products or any other drugs intended for use during th * Prolonged QTcF \>450 ms or shortened QTcF \<350 ms or family history of long QT syndrome.