This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days: * day 1: On day time administration of LPS. * day 2: On night time administration of LPS. * day 3: On day time administration of LPS + Placebo. * day 4: On day time administration of LPS + melatonin. * day 5: On night time administration of LPS + placebo. * day 6: On night time administration og LPS + melatonin. Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
12
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
Herlev Hospital
Herlev, Denmark
Inflammatoric markers
IL-6 TNF-alpha YKL-40
Time frame: measured before and after the administration of LPS endotoxin.
Oxidative markers
Vit C MDA (malondialdehyde)
Time frame: measured before and after the administration of LPS endotoxin.
Secondary outcome
Holter Fatigue Karolinska Sleepness scale Blood pressure Heart rate Temperature
Time frame: constant measurment
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