The following are the study hypothesis: * Secretin administration compared to placebo will result in a statistically significantly greater percentage of collected fluid samples being predominantly of exocrine pancreas origin when samples are duodenal aspirates. * Secretin administration compared to placebo will result in a statistically significantly greater percentage of collected fluid samples meeting the minimum specifications for use in the indicated laboratory test of DNA mutational analysis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Enrollment
64
Human Secretin for Injection
Saline for Injection
Saint Louis University
St Louis, Missouri, United States
Endoscopic Sample
Is Volume ≥ 3.5 mL Is HCO3 concentration ≥ 40 mEq/L Is DNA mutational analysis (K-ras-2 gene Fluorescence peak height ≥ 50 Relative Florescence Units panel assessable markers informative ≥ 8). (Note- The outcome value is boolean (yes or no) as an answer).
Time frame: First 5 minutes after treatment administration
Volume of Fluid ≥ 3.5mL (Boolean Expression Evaluated as Yes or no).
Volume of pancreatic fluid. The volume is the number of mL of pancreatic fluid.
Time frame: First 5 minutes after treatment administration
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