Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

Herlev Hospital279 enrolled

Overview

The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.

Study Type

OBSERVATIONAL

Enrollment

279

Conditions

Genotype Cognitive Impairment

Interventions

GenotypingGENETIC

Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia Exclusion Criteria: * daily use of major tranquilizers or antipsychotic medication * known disease of the CNS * score less than 24/30 points in MMSE

Locations (1)

Herlev Hospital - Gastro unit

Herlev, Denmark

Outcomes

Primary Outcomes

HPER3 genotype

Time frame: 3 months

Secondary Outcomes

Post-operative morbidity

Time frame: ½ year

Data from ClinicalTrials.gov

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