Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction. In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics. The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health. A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
Study Type
OBSERVATIONAL
Enrollment
850
Alberta infant motor scale Griffiths test Kauffmann ABC
Schleswig- Holstein University, Campus Lübeck, Department of Reproductive Medicine
Lübeck, Schleswig-Holstein, Germany
Maternal pregancy outcome
spontaneous or operative delivery, birth injuries, conjoined morbidity
Time frame: 7 years
embryo survival
embryo survival rate
Time frame: 7 years
infant health
infant vital characteristics (APGAR, arterial cord ph), infant development: only develomental milestones: sitting, standing, walking infant morbidity
Time frame: 7 years
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