Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency

Inclusion Criteria: * Adult patients (male and female) between 18 and 75 years * 1 -12 month after TBI or SAH before prescreening * Cortisol level 100-180 ng/ml after stimulation with ACTH * Written informed consent by patient or a legally accepted representative Exclusion Criteria: * Pregnancy and lactation period (during study treatment) * Concomitant or previous high-dose therapy with glucocorticoids; previous treatment with glucocorticoids will be accepted, if it has been low dose (i.e. lower than the Cushing threshold) and has been stopped at least 3 months before study participation * Suspected or known hypersensitivity to hydrocortisone or any of its components * Albumine less than 2,5 g/dl * Suspected or known drug or alcohol abuse * Planned treatment for thyroid dysfunction or a planned change in established thyroid treatment * Any condition which in the opinion of the investigator makes the patient unsuitable for inclusion. * Participation in another clinical trial with investigational new drugs * Severe medical or psychiatric disease * Change of dosage of any other drug which might influence the corticotrope axis or cognitive function (e.g. antidepressive treatment) during the last 3 weeks * Oral contraceptives * Severe disturbances in articulation, visual faculty or hearing * Any elective surgery or medical treatment planned in the observation period * Intensive Care treatment