The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines

Seoul National University Hospital241 enrolled

Overview

Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.

For the population being undergone with bronchoscopy, the clinical signs and procedural measures for complication of bronchoscopy and cytokines will be checked.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

241

Conditions

Fever Pneumonia

Interventions

oral amoxicillin/clavulanate 1g (875/125mg)DRUG

oral amoxicillin/clavulanate 1g (875/125mg) on the day of the procedure 30 minutes prior to the FB

controlDRUG

no intervention with the same procedure of FB

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients (aged 18 years or older) who underwent FB Exclusion Criteria: * concurrent treatment with antibiotics or systemic corticosteroid

Outcomes

Primary Outcomes

The incidence of fever

time frame for body temperature 24hr before and after bronchoscopy every 4hrs

Time frame: 24 hr after bronchoscopy

Secondary Outcomes

change of serum cytokines level

Time frame for cytokine measurement 24hr before brochoscopy - 1hr after bronchosocpy - 24hr after brochoscopy

Time frame: before bronchoscopy and 24hr after bronchoscopy

Data from ClinicalTrials.gov

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