Effect of Aldosterone Blockade on Arterial Compliance

Wolfson Medical Center51 enrolled

Overview

The present study investigated the long-term (12 months) effect of spironolactone treatment on glucose homeostasis, metabolic parameters and vascular properties.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Arterial Stiffness Arterial Elasticity

Interventions

SpironolactoneDRUG

Spironolactone orally, at a dose of 50 mg/day for 12 months

Eligibility

Sex: ALLMin age: 45 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1\. patients with type 2 diabetes mellitus Exclusion Criteria: 1. history of unstable angina, myocardial infarction (MI), cerebrovascular accident (CVA) 2. major surgery within the six months preceding entrance to the study 3. unbalanced endocrine disease 4. any disease that might affect absorption of medications 5. plasma creatinine \>2.5 mg/dl 6. elevation of liver enzymes to more that twice the upper normal limit 7. plasma potassium levels \>5.5 mg/dl

Locations (1)

Wolfson Medical Center

Holon, Israel

Data from ClinicalTrials.gov

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