Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage

Institut National de la Santé Et de la Recherche Médicale, France30 enrolled

Overview

The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals. The respective roles of viral replication, bacterial infection and immune alterations of the host during such severe influenza H1N1v infection need to be clarified in order to optimize patients care. In this context, we aim to study immune and virological parameters in bronchoalveolar lavage fluid during severe influenza A/H1N1v infection with pulmonary involvement in intensive care unit. Results will be correlated to bacterial or viral pulmonary co-infections and to peripheral blood immune and virological parameters.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Influenza Acute Lung Injury Acute Respiratory Distress Syndrome

Eligibility

Sex: ALLMin age: 13 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Suspected influenza A/H1N1 infection * Diffuse bilateral pneumonia \<96h with acute lung injury or respiratory distress syndrome * Invasive or non-invasive ventilation in intensive care unit * Age \> 13 Exclusion Criteria: * Other cause identified of acute lung injury or acute respiratory distress syndrome * Contraindicated bronchoalveolar lavage

Locations (2)

Outcomes

Primary Outcomes

immunological parameters in blood and bronchoalveolar lavage fluid

Time frame: day 0 and day 5-7 of ventilation for both blood and BAL, day 30 and month 5 for blood

Secondary Outcomes

virological parameters in nose, broncho-alveolar lavage and peripheral blood

Time frame: day 0 and day 5-7 of ventilation