Dose Response Bioavailability of Coffee and Green Tea Antioxidants in Humans

Société des Produits Nestlé (SPN)23 enrolled

Overview

Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 - 65 years, male and female * Healthy as determined by the medical questionnaire and the medical visit * Normal weight: BMI 18 - 25 * Coffee drinkers with an average consumption of 2-5 cups per day * Having given informed consent Exclusion Criteria: * Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer * Have had a gastrointestinal surgery, except appendicectomy * Difficulty to swallow * Have a regular consumption of medication * Have taken antibiotic therapy within the last 6 months * Alcohol consumption \> 2 units a day * Smokers (more than 5 cigarettes per day) * Have given blood within the last 3 weeks * Volunteers who cannot be expected to comply with treatment * Currently participating or having participated in another clinical trial during the last 3 weeks

Outcomes

Primary Outcomes

Compare plasma Area under the curve (AUC) of highest and lowest dose of coffee for chlorogenic and phenolic acid metabolites

Time frame: Measurements done over 24h after ingestion

Secondary Outcomes

Compare Area under the curve (AUC), Maximum plasma concentration (Cmax), Time to reach maximum plasma concentration (Tmax) and half-life (T1/2) of all three doses of coffee for chlorogenic and phenolic acid metabolites

Time frame: Measurements done over 12h after ingestion

Compare AUC, Cmax, Tmax and T1/2 of all three doses of green tea for catechin metabolites